ASTEX THERAPEUTICS LIMITED

436 CAMBRIDGE SCIENCE PARK, MILTON ROAD, CAMBRIDGE, CB4 0QA

Previous name: ASTEX TECHNOLOGY LIMITED (changed on 27-Jun-2005)

Company Number: 03751674
Incorporation date: 14-Apr-1999
Status: Active
Entity type: Private Limited Company

SIC codes:
72110 Research and experimental development on biotechnology

SUMMARY

This company is 25.5 years old and is currently active. It is controlled by Otsuka America Inc. The company has positive equity (net assets) of GBP 136 million which has increased from GBP 89 million in the previous year. The latest reported revenue figure is GBP 202.5 million which is up 70% on previous year's figure of GBP 117.2 million. The company has 5 active officers (directors or partners) who are or were officers of 10 other companies, 2 (20.0%) of which have since been dissolved or are proposed for strike off. The company has no public disputes filed on the Business Disputes Register. There is one court case involving the company that we are aware of.

FINANCIALS (BETA)

Next accounts due: 30-Sep-2025
Accounts Filed: FULL (31-Dec-2023)

P&L Financials:

Year end	Currency	Revenue	Operating profit	Interest Received	Interest Paid	Tax	Net Profit GBP
31-Dec-2023	GBP	202,455,603	138,705,487		2,139,372	14,565,802	122,000,313
31-Dec-2022	GBP	117,178,479	69,063,399	5,786,929	-4,239,411	7,576,453	65,726,357
31-Dec-2021	GBP	92,355,171	45,518,901	747,700	565,463	5,833,480	39,867,658
31-Dec-2020	GBP	79,022,451	34,713,867	75,291	1,419,477	3,507,011	29,862,670
31-Dec-2019	GBP	76,516,397	33,569,546		-1,102,178		28,999,130
31-Dec-2018	GBP	5,549,323	895,703		16,740		960,881
31-Dec-2017	GBP	55,493,232	8,957,032		167,397		9,608,806
31-Dec-2016	GBP	54,148,447	21,368,882		384,194
31-Dec-2014	GBP	33,347,903	7,274,489
31-Dec-2012	GBP	8,238,482	-17,063,510				-13,980,287
31-Dec-2011	GBP	13,770,634	-6,542,685				-4,421,866

Balance Sheet Financials:

Year end	Currency	Cash	Current Assets	Current Liabilities	Share Capital	Premium Reserve	Retained Earnings	Net Assets
31-Dec-2023	GBP	75,794,372	138,795,915	8,541,038				136,032,406
31-Dec-2022	GBP	38,101,162	72,309,024	5,128,577	100		89,031,993	89,032,093
31-Dec-2021	GBP	32,385,438	58,591,191	9,565,823	100		73,305,636	73,305,736
31-Dec-2020	GBP	17,706,970	38,837,790	38,772,374	100		58,437,978	58,438,078
31-Dec-2019	GBP	23,936,010	37,700,504	-7,915,444	100		53,575,308
31-Dec-2018	GBP	16,609,707	36,145,490		100	1,251,037		49,576,279
31-Dec-2017	GBP	8,063,278	20,562,000		100	13,251,037		33,570,140
31-Dec-2016	GBP	33,247,652	50,778,664		24,846	123,022,317		51,961,334
31-Dec-2014	GBP	10,184,159	18,495,203	4,268,638	24,846	123,022,317	-105,028,245	18,018,918
31-Dec-2012	GBP	1,491,100	5,932,204	15,082,240	24,846	81,771,280	-88,314,783	-6,518,657
31-Dec-2011	GBP	8,120,864	14,296,081		24,846		-74,570,084	7,226,042

DISPUTES

No disputes filed on www.disputesregister.org

COMPANY SECRETARY

Status	Name	Appointed on	Resigned on	Occupation	Nationality	All apointments (active/resigned)
Active	Neil Steven JONES	29 Jun 2000	07 Oct 2024	Financial Controller	British	1 - 0
Resigned	James Foster ABELL	18 May 1999	29 Jun 2000	Venture Capital Manager	British	0 - 21

DIRECTORS

Status	Name	Appointed on	Resigned on	Occupation	Nationality	All appointments (active/resigned)	Dissolved companies (rate)
Active	Yasuhisa KUROGI	01 Mar 2024		None	Japanese	1 - 0	0 (0.0%)
Resigned	Michael Edward GEHRKE	01 Mar 2023	01 Mar 2024	None	American	0 - 1	0 (0.0%)
Active	Toshiki SUDO	23 May 2015		None	Japanese	1 - 1	0 (0.0%)
Active	Thomas Leon, Professor Sir BLUNDELL	01 Jan 2014		None	British	2 - 8	3 (30.0%)
Resigned	Mohammad, Dr. AZAB	01 Jan 2014	11 Apr 2022	President And Cmo	Canadian,French	0 - 1	0 (0.0%)
Resigned	Andrew, Dr BODNAR	01 Jan 2014	31 Dec 2020	Physican	American	0 - 1	0 (0.0%)
Active	Robert Dwyer, Dr. MCQUADE	01 Jan 2014		Evp/Chief Strategic Officer	American	1 - 0	0 (0.0%)
Resigned	James S J, Dr MANUSO	20 Jul 2011	01 Jan 2014	Chairman, President, And Ceo	American	0 - 1	0 (0.0%)
Resigned	Michael MOLKENTIN	20 Jul 2011	01 Jan 2014	Chief Financial Officer And Corporate Secretary	Us Citizen	0 - 1	0 (0.0%)
Resigned	Ismail, Dr KOLA	01 May 2010	20 Jul 2011	Executive Vice President And President New Medicin	American And Australian	0 - 1	0 (0.0%)
Resigned	Edmund Martin OLIVER DE VEZIN	15 Sep 2009	20 Jul 2011	Financier	American	0 - 1	0 (0.0%)
Resigned	Robert Martin, Dr BUCKLAND	17 Jul 2008	01 Jan 2014	Cbo	British	0 - 1	0 (0.0%)
Resigned	John Christopher ASTON	30 Apr 2007	11 May 2010	Finance Director	British	0 - 2	0 (0.0%)
Resigned	Leon Ramsey BUSHARA	13 Jul 2006	16 Jan 2008	Ceo	American	0 - 1	0 (0.0%)
Resigned	Peter Stuart, Dr RINGROSE	01 Jan 2005	20 Jul 2011	Consultant	British	0 - 1	0 (0.0%)
Resigned	Amos Meir GOREN	10 Dec 2003	20 Jul 2011	Venture Capitalist	Israeli	0 - 5	1 (20.0%)
Resigned	Peter John, Dr FELLNER	27 Mar 2002	20 Jul 2011	Company Director	British	0 - 50	28 (56.0%)
Resigned	Jon Sheldon SAXE	10 Dec 2001	30 Apr 2010	Non Executive Director	American	1 - 1	0 (0.0%)
Resigned	Mark CARTHY	18 May 2001	23 Jul 2009	Finance	American	0 - 2	0 (0.0%)
Resigned	Patrick VAN BENEDEN	24 Apr 2001	20 Jul 2011	Venture Capitalist	Belgian	0 - 2	1 (50.0%)
Resigned	Timothy John HAINES	29 Jun 2000	13 Jul 2006	Chief Executive	British	4 - 15	6 (31.6%)
Resigned	Timothy John HAINES	29 Jun 2000	13 Jul 2006	Chief Executive	British	10 - 5	6 (40.0%)
Resigned	Timothy James, Dr RINK	29 Feb 2000	09 Jun 2004	Chairman	British	0 - 7	4 (57.1%)
Resigned	Simon Fraser CAMPBELL	29 Feb 2000	27 Mar 2002	Chemist	British	0 - 4	2 (50.0%)
Resigned	Edmund Martin OLIVIER DE VEZIN	19 Oct 1999	18 May 2001	Financier	American	0 - 1	0 (0.0%)
Resigned	Thomas Leon, Professor Sir BLUNDELL	18 May 1999	20 Jul 2011	Professor	British	2 - 8	3 (30.0%)
Resigned	Stephen William, Dr BUNTING	18 May 1999	20 Jul 2011	Investment Manager	British	0 - 24	10 (41.7%)
Resigned	James Foster ABELL	18 May 1999	29 Jun 2000	Venture Capital Manager	British	0 - 21	7 (33.3%)
Resigned	Roberto Celeste Ercole SOLARI	18 May 1999	29 Jun 2000	Investment Analyst	British,Italian	1 - 8	3 (33.3%)
Active	Harren JHOTI	18 May 1999		Ceo	British	1 - 1	0 (0.0%)
Resigned	Christopher, Professor ABELL	18 May 1999	29 Jun 2000	University Lecturer	British	0 - 4	1 (25.0%)
Resigned	MITRE SECRETARIES LIMITED	14 Apr 1999	18 May 1999			5 - 856	476 (55.3%)
Resigned	William WARNER	14 Apr 1999	18 May 1999	Chartered Secretary	British	0 - 87	32 (36.8%)
Resigned	Michael William RICH	14 Apr 1999	18 May 1999		British	0 - 167	72 (43.1%)

Number of active directors: 5
Average tenure of active directors: 11.4 years
Average tenure of resigned directors: 4.6 years
Average active director Dissolution Rate: 6.0%

DIRECTOR APPOINTMENTS IN OTHER COMPANIES

Name	Yasuhisa KUROGI	Toshiki SUDO	Thomas Leon, Professor Sir BLUNDELL	Robert Dwyer, Dr. MCQUADE	Harren JHOTI
BIOINDUSTRY ASSOCIATION (01889626) - Active					✔
CELLTECH GROUP LIMITED (02159282) - Active			✔
LAT TRUST COMPANY LIMITED (02566975) - Active			✔
THE BABRAHAM INSTITUTE (03011737) - Active			✔
OTSUKA PHARMACEUTICAL EUROPE LTD. (03456326) - Active		✔
ASTEX THERAPEUTICS LIMITED (03751674) - Active	✔	✔	✔	✔	✔
THE BIOSCIENCES FEDERATION (04600861) - Dissolved			✔
BLUNDELL BIOSCIENCE (CAMBRIDGE) LIMITED (06543177) - Dissolved			✔
THE DAPHNE JACKSON MEMORIAL FELLOWSHIPS TRUST (06621472) - Active			✔
BLUNDELL BIOSCIENCE SHEPRETH LIMITED (07679938) - Dissolved			✔
BLUNDELL BIOSCIENCE RUSHMOOR LIMITED (09994491) - Active			✔

SHAREHOLDERS (BETA)

Shareholder name	Share class	Shares at confirmation date
Shareholder name	Share class	2018-04-05	2013-04-05
OTSUICA AMWACA YOR	ORDNHAX	1 100%	0 0%
ASIGX PUATIMNA CSI) CALS	CRO WARY	0 0%	24 100%

SHAREHOLDINGS (BETA)

no shareholding data

CONTROLLED COMPANIES / CONTROLLING ENTITIES

>75%:Otsuka America Inc (2199821 - Usa) active

Controlling entities above

ASTEX THERAPEUTICS LIMITED

no controlled companies

LATE PAYMENTS REPORT

Start date	End date	Average days to pay	% invoices paid over 60 days	% invoices not paid within agreed terms	Gov.uk report
2023-07-01	2023-12-31	14	1%	19%	80892
2023-01-01	2023-06-30	13	0%	16%	75168
2022-07-01	2022-12-31	13	1%	15%	65657
2022-01-01	2022-06-30	13	1%	13%	59609
2021-07-01	2021-12-31	15	1%	17%	52807
2021-01-01	2021-06-30	18	1%	21%	45763
2020-07-01	2020-12-31	20	1%	27%	39365
2020-01-01	2020-06-30	17	1%	18%	32378
2019-07-01	2019-12-31	19	2%	22%	25228
2019-01-01	2019-06-30	16	2%	16%	18149
2018-07-01	2018-12-31	18	2%	21%	9743
2018-01-01	2018-06-30	18	1%	21%	6224

COURT CASES

Date	Title	Reference	Subject
2018-11-06	Astex Therapeutics Ltd v Astrazeneca AB	[2018] EWCA Civ 2444

PATENTS

Title	Date filed	Status	Publication number
Crystal structure of cytochrome P450 3A4 and its use	2003-10-24	Ceased	GB2395718
Crystal structure of cytochrome p450 3a4 and its use	2003-10-24	Ceased	GB2408509

COMPETITORS

(Based on Sic code: 72110 Research and experimental development on biotechnology)

Company	Registered Address	Company Number	YE Date	Revenue GBP	Net Profit GBP	Other SIC codes
ILLUMINA CAMBRIDGE LIMITED	19 GRANTA PARK, GREAT ABINGTON, CAMBRIDGE, CAMBRIDGESHIRE, ENGLAND, CB21 6DF	03625145	2017-12-31	2,114,848,000	422,140,000
IQVIA LTD.	3 FORBURY PLACE, 23 FORBURY ROAD, READING, UNITED KINGDOM, RG1 3JH	03022416	2017-12-31	1,123,545,000	198,818,000
AMGEN LIMITED	216 CAMBRIDGE SCIENCE PARK, MILTON ROAD, CAMBRIDGE, CAMBRIDGESHIRE, ENGLAND, CB4 0WA	02354269	2017-12-31	238,931,000	9,488,000
GENOME RESEARCH LIMITED	WELLCOME SANGER INSTITUTE WELLCOME GENOME CAMPUS, HINXTON, SAFFRON WALDEN, ENGLAND, CB10 1SA	02742969	2018-09-30	144,812,000	55,555,000
COVANCE LABORATORIES LIMITED	OTLEY RD, HARROGATE, HG3 1PY	01171833	2017-12-31	111,519,000	16,839,000
ASTEX THERAPEUTICS LIMITED	436 CAMBRIDGE SCIENCE PARK, MILTON ROAD, CAMBRIDGE, CB4 0QA	03751674	2018-12-31	72,199,766	28,006,138
CELLTECH R&D LIMITED	208 BATH ROAD, SLOUGH, BERKSHIRE, SL1 3WE	01472269	2017-12-31	55,407,000	-5,338,000
QUOTIENT SCIENCES LIMITED	TRENT HOUSE MERE WAY, RUDDINGTON FIELDS BUSINESS PARK, RUDDINGTON, NOTTINGHAM, NG11 6JS	05221615	2018-03-31	43,379,000	7,170,000
CENTRE FOR PROCESS INNOVATION LIMITED	WILTON CENTRE, WILTON, REDCAR, CLEVELAND, TS10 4RF	05002194	2018-03-31	33,187,000	7,344,000	72190-Other research and experimental development on natural sciences and engineering 82990-Other business support service activities not elsewhere classified 85320-Technical and vocational secondary education
EVOTEC (UK) LIMITED	114 INNOVATION DRIVE, MILTON PARK, MILTON, ABINGDON, OXFORDSHIRE, OX14 4RZ	02674265	2017-12-31	31,859,000	1,599,000
ARC TRINOVA LIMITED	C/O QUOTIENT SCIENCES LIMITED TRENT HOUSE MERE WAY, RUDDINGTON FIELDS BUSINESS PARK, RUDDINGTON, NOTTINGHAM, ENGLAND, NG11 6JS	09767194	2017-12-31	8,422,519	0
CROWN BIOSCIENCE UK LIMITED	BUILDING 14 DODGEFORD LANE, OSGATHORPE, LOUGHBOROUGH, LEICESTERSHIRE, LE12 9TE	07109059	2017-12-31	2,819,775	0
INDUSTRIAL MICROBIOLOGICAL SERVICES LIMITED	ODD FELLOWS HALL, 118B OXFORD ROAD, READING, RG1 7NG	03264423	2018-01-31	1,005,784	0
THE BIO NANO CENTRE UNLIMITED	69 ONSLOW ROAD, ONSLOW ROAD, RICHMOND, ENGLAND, TW10 6QA	06389520	2018-02-28	974,607	0
TAILORED CLINICAL RESEARCH SOLUTIONS LIMITED	2 HINKSEY COURT, CHURCH WAY, OXFORD, ENGLAND, OX2 9SX	09930195	2017-12-31	334,157	0	86900-Other human health activities
NEXT CLINICAL RESEARCH ORGANISATION LIMITED	47 THE RIDGEWAY, FRIERN BARNET, LONDON, ENGLAND, N11 3LG	09418105	2018-12-31	282,733	0
MEDEZRIN LTD.	71-75 SHELTON STREET, COVENT GARDEN, LONDON, UNITED KINGDOM, WC2H 9JQ	03340737	2018-03-31	170,000	0
NEW DIAGNOSTICS LIMITED	KNOLE VIEW, SOUTH HILL, SOMERTON, SOMERSET, TA11 7JQ	08672341	2019-03-31	104,307	0	74909-Other professional, scientific and technical activities not elsewhere classified
CLINICAL PHASE DEVELOPMENT LTD	38 CABERFEIGH CLOSE, REDHILL, ENGLAND, RH1 6BF	07715640	2018-07-31	94,690	0
SEE-THROUGH SCIENTIFIC LIMITED	HARWOOD HOUSE, 43 HARWOOD ROAD, LONDON, ENGLAND, SW6 4QP	09410281	2017-12-31	76,514	0
DIAGNODUS LTD	ST JOHN'S INNOVATION CENTRE, COWLEY ROAD, CAMBRIDGE, ENGLAND, CB4 0WS	07600875	2019-04-30	63,322	0
FISHER STATISTICS CONSULTANCY LIMITED	10 HEDGEHOG CRESCENT, EDINBURGH, SCOTLAND, EH17 8XP	SC385170	2018-09-30	54,959	0	72200-Research and experimental development on social sciences and humanities 85600-Educational support services
SERNAT LIMITED	173 BROADWAY, DIDCOT, ENGLAND, OX11 8RZ	10372226	2017-09-30	51,815	0	72200-Research and experimental development on social sciences and humanities 86210-General medical practice activities
COULSON BIOINFORMATICS LTD	EXCHANGE BUILDING, 66 CHURCH STREET, HARTLEPOOL, UNITED KINGDOM, TS24 7DN	10904839	2018-08-31	48,628	0
IHG PHARMACO LIMITED	20-22 WENLOCK ROAD, LONDON, N1 7GU	05606880	2018-03-31	43,960	0
CALA PHARMA LIMITED	5 FARRIERS WAY, WINSFORD, ENGLAND, CW7 2TS	09883439	2017-11-30	35,084	0
GOLGENE TECHNOLOGIES LIMITED	9 CHURCH LANE, BISHOPSTON, SWANSEA, WALES, SA3 3JT	06069931	2019-01-31	35,041	0
GREENSTONE BIOLABS LTD	024, WESTBOURNE STUDIOS, ACKLAM ROAD, LONDON, ENGLAND, W10 5JJ	09874376	2017-11-30	33,043	0	72190-Other research and experimental development on natural sciences and engineering
APPLIED EXOMICS LTD	LEE LARCOMBE, 39 HOGSDEN LEYS, ST. NEOTS, CAMBRIDGESHIRE, PE19 6AD	08251827	2018-10-14	15,705	0
SP SCIENTIFIC SERVICES LTD	52 ANGEL HILL, SUTTON, UNITED KINGDOM, SM1 3EW	10312528	2018-08-31	15,229	0	72190-Other research and experimental development on natural sciences and engineering
CHEMOVATION LIMITED	WA10 1GH, 49 ARRIVATO PLAZA, HALL STREET, ST HELENS, UNITED KINGDOM, WA10 1GH	05316858	2018-12-31	12,182	0	74909-Other professional, scientific and technical activities not elsewhere classified
AXONICS MODULATION TECHNOLOGIES, U.K. LIMITED	5TH FLOOR, ONE NEW CHANGE, LONDON, UNITED KINGDOM, EC4M 9AF	09622653	2019-06-30	8,610	0
RIOTECH PHARMACEUTICALS LIMITED	49 ARRIVATO PLAZA,, HALL STREET, ST HELENS, UNITED KINGDOM, WA10 1GH	04316377	2018-11-30	8,428	0
GENOMEX LTD	129C LIME WALK, HEADINGTON, OXFORD, ENGLAND, OX3 7AD	10356872	2018-09-30	7,923	0	72190-Other research and experimental development on natural sciences and engineering
ALLERAYDE SAB LIMITED	1 MEADOW ROAD, NEWARK, NG24 3BP	07909304	2019-01-31	4,348	0
BIOMEMS TECHNOLOGIES LIMITED	272 THE HAWTHORNS, CARDIFF, WALES, CF23 7AN	09360659	2018-12-31	3,000	0
OXFORD MEDISTRESS LTD	FLAT 1, 69, ONSLOW ROAD, RICHMOND, SURREY, ENGLAND, TW10 6QA	05470178	2017-06-30	2,589	0	86900-Other human health activities
ALCHEMY PHARMATECH LIMITED	9 WATCOMBE ROAD, WATLINGTON, ENGLAND, OX49 5QJ	07912825	2017-03-31	1,981	0
PHYTOFUTURES LTD	54 DAWLISH ROAD, LONDON, ENGLAND, E10 6QD	09412092	2019-01-31	637	0	74909-Other professional, scientific and technical activities not elsewhere classified
ALBANY CLINICAL CONSULTING LIMITED	7 NEW BROUGHTON, EDINBURGH, MIDLOTHIAN, UNITED KINGDOM, EH3 6PA	SC532187	2018-04-30	295	0
DYAX LTD	1 KINGDOM STREET, LONDON, ENGLAND, W2 6BD	08965623	2017-12-31	0	0	99999-Dormant Company
ACUBLATE LIMITED	ANGEL BUILDING, 407 ST. JOHN STREET, LONDON, EC1V 4AD	07209117	2018-03-31	0	0
ARWAIN YMLAEN LIMITED	32 CEDAR AVENUE, HAZLEMERE, HIGH WYCOMBE, HP15 7DW	06062248	2019-03-31	0	0
CELL RESEARCH TECHNOLOGY LTD	32 FRIENDSHIP ROAD, BRISTOL, BS4 2RN	08192207	2018-08-31	0	0
DE NOVO PHARMACEUTICALS LIMITED	GILMARDE HOUSE, 47 SOUTH BAR STREET, BANBURY, OXFORDSHIRE, ENGLAND, OX16 9AB	03761178	2018-09-30	0	0
FERTILITY INNOVATIONS LIMITED	COOMBE HOUSE, BRADFORD PEVERELL, DORCHESTER, DORSET, DT2 9SE	07416896	2018-12-31	0	0
GARSINGTON TECHNOLOGIES LIMITED	4, THE GABLES, VALE OF HEALTH, HAMPSTEAD, LONDON, ENGLAND, NW3 1AY	08782927	2018-11-30	0	0
IOTA PHARMACEUTICALS LIMITED	ST JOHNS INNOVATION CENTRE, COWLEY ROAD, CAMBRIDGE, CAMBRIDGESHIRE, CB4 0WS	06279987	2018-06-30	0	0
LIF NANO RX LTD	APARTMENT 16 SPRINGS COURT, FIELD CLOSE, COTTINGHAM, ENGLAND, HU16 5GX	08551193	2018-05-31	0	0
MARBLEAMBER LIMITED	29 GLADSTONE STREET, HATHERN, LOUGHBOROUGH, LEICESTERSHIRE, LE12 5LE	07121238	2019-03-31	0	0
NANO-NOSE LIMITED	41 OAKWOOD PARK ROAD, LONDON, ENGLAND, N14 6QD	11014188	2018-07-31	0	0
PT VENTURES LIMITED	1A TOWER ROAD, DARTFORD, ENGLAND, DA1 2HE	09821026	2018-10-31	0	0
W C LEE LIMITED	94 HOWARD AVENUE, SLOUGH, BERKSHIRE, ENGLAND, SL2 1LA	09508311	2018-03-31	0	0
WALTERSTEAD LIMITED	ACADEMY HOUSE, SHEDDEN PARK ROAD, KELSO, ROXBURGHSHIRE, TD5 7AL	SC368318	2018-03-31	0	0	75000-Veterinary activities 82990-Other business support service activities not elsewhere classified
RESPIRATORY CLINICAL TRIALS LIMITED	1 TOWER HOUSE, TOWER CENTRE, HODDESDON, HERTFORDSHIRE, ENGLAND, EN11 8UR	04063160	0000-00-00	0	0

LIQUIDATION RISK (BETA)

This company is Active. Statistically, Active companies have a low probability of being liquidated within a year.
Here are our probability predictions:

Basis	Liquidation within 3 months	Liquidation within 6 months	Liquidation within 12 months	Prediction confidence
ASTEX THERAPEUTICS LIMITED	0.8%	2.4%	4.9%	Medium
Other companies Active in the same sector	1.2%	3.5%	7.4%	Medium


Age	0.3%	1.3%	2.4%	Medium
Company Type	0.7%	3.7%	7.4%	Medium
Accounts category	0.7%	2.2%	3.8%	Medium
Accounting Month	0.6%	2.4%	5.5%	Medium
Sic code count	0.7%	3.5%	7.0%	Medium